What Substance P is
Substance P is an endogenous neuropeptide involved in pain transmission, inflammation context, and neuroimmune signaling.
Substance P is grouped under Endogenous / Biology / Fitness + Recovery on PeptideFactCheck because it shows up whenever people want to understand pain and inflammation signaling at the peptide level.
The useful starting point is to separate the molecule itself from the internet story around it. It shows up whenever people want to understand pain and inflammation signaling at the peptide level.
Why people keep looking it up
It shows up whenever people want to understand pain and inflammation signaling at the peptide level.
Substance P is an endogenous neuropeptide involved in pain transmission, inflammation context, and neuroimmune signaling.
Substance P tends to stay in the conversation because it touches a familiar public theme: neuropeptide, pain signaling, and inflammation context. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
High-relevance reference entry for pain and inflammatory peptide biology.
Human biology is established, but that is different from claiming a simple therapeutic peptide intervention.
Mechanistic support is broad across pain and inflammatory physiology.
Why this page carries the current tier: High-relevance reference entry for pain and inflammatory peptide biology.
The current seed trail for Substance P is pulling from 2 databases sources and 1 literature source.
Safety, limits, and regulatory context
This is a biology-reference peptide, not a clean shortcut to a consumer-use product.
Substance P is tracked here as endogenous biology.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for Substance P. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for Substance P is CID 36511. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 36511
- Formula
- C63H98N18O13S
- Molecular weight
- 1347.6
- InChIKey
- ADNPLDHMAVUMIW-CUZNLEPHSA-N
Matched synonyms include Substance P, 33507-63-0, Neurokinin P, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, Neuropeptide sp-1, Sh-oligopeptide-73, Substance p (1-11), 675VGV5J1D.
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for Substance P returns 141 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
Literature snapshot
The current PubMed query for Substance P returns 26553 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.