What Epithalon is
Epithalon is discussed as a short synthetic peptide associated with aging biology claims, including telomerase-related narratives.
Epithalon is grouped under Longevity + Skin on PeptideFactCheck because it is a recurring longevity peptide in biohacking circles because the story is clean, dramatic, and often overstated.
The useful starting point is to separate the molecule itself from the internet story around it. It has a clean longevity story that is easy to repeat online.
Why people keep looking it up
People talk about epithalon for longevity, sleep rhythm, telomeres, and anti-aging.
Epithalon is a short peptide discussed in aging-biology narratives, especially around telomerase-related claims.
Epithalon tends to stay in the conversation because it touches a familiar public theme: telomerase discussion, aging biology, and pineal peptides. That makes it easy for the claim to travel faster than the evidence.
What the evidence can support right now
Human evidence is limited. Lifespan and anti-aging claims need much more caution.
Human evidence is limited and uneven, especially for broad lifespan or anti-aging claims.
Preclinical and mechanistic claims have driven much of the interest.
Why this page carries the current tier: Limited human evidence plus heavy online extrapolation.
The current seed trail for Epithalon is pulling from 1 literature source, 1 trials source, 1 databases source, and 1 safety source.
Safety, limits, and regulatory context
The main risk is fake certainty: aging endpoints are hard, long-term data is limited, and products vary.
No FDA-approved epithalon drug product is listed in this V1 source trail.
Editorial boundary: PeptideFactCheck does not publish dosing, cycling, sourcing, injection, or administration instructions for Epithalon. The job here is to explain the public claim, the mechanism story, the evidence strength, and the current limits.
Molecular and identifier data
The current PubChem match for Epithalon is CID 219042. That gives the page a source-backed chemistry record rather than a placeholder identifier block.
- PubChem CID
- 219042
- Formula
- C14H22N4O9
- Molecular weight
- 390.35
- InChIKey
- HGHOBRRUMWJWCU-FXQIFTODSA-N
Matched synonyms include Epitalon, 307297-39-8, Epithalon, Epithalone, Ala-Glu-Asp-Gly, AE-0 peptide, Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-, O65P17785G.
Open PubChem recordClinical trial snapshot
The current ClinicalTrials.gov intervention query for Epithalon returns 1 study records. This does not prove efficacy by itself, but it does show whether the peptide is showing up in a formal trial registry rather than only in forums or vendor copy.
Literature snapshot
The current PubMed query for Epithalon returns 138 results. The articles below are a quick literature surface so the page shows actual papers instead of only generic evidence labels.
Source trail
Each linked source is shown directly so the page can be audited. The page now combines its editorial seed trail with automated official-source enrichment generated on 2026-04-24 from PubChem, ClinicalTrials.gov, PubMed, DailyMed, openFDA label, and Drugs@FDA.